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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Advance Access published online on April 7, 2009
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, doi:10.1093/gerona/glp026
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© The Author 2009. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Age-Related Deficit in Load-Induced Skeletal Muscle Growth

Darren T. Hwee and Sue C. Bodine

Department of Neurobiology, Physiology, and Behavior, University of California, Davis

Address correspondence to Sue C. Bodine, PhD, Department of Neurobiology, Physiology, and Behavior, University of California, Davis, One Shields Avenue, Davis, CA 95616. Email: scbodine{at}ucdavis.edu


  Abstract

The growth response of ankle flexor and extensor muscles to two models of increased loading, functional overload (FO) and hind-limb reloading following hind-limb suspension, was measured by wet weight in Fisher 344–Brown Norway rats at ages ranging from 6 to 30 months. In response to FO, there was a 40% decrease in absolute growth of the plantaris beginning in middle age. Interestingly, the growth response to FO of 30-month old rats maintained on a 40% calorie-restricted diet improved by more than twofold relative to 30-month old rats on a normal chow diet. Recovery of muscle mass upon reloading following disuse was significantly impaired (reduced 7–16%) in predominantly fast, but not slow, muscles of 30-month relative to 9-month old rats. Initial investigation of the Akt signaling pathway following FO suggests a reduction or delay in activation of Akt and its downstream targets in response to increased loading in old rats.

Keywords Hypertrophil; Akt; Calorie-restriction

Received: September 2, 2008; Accepted: February 22, 2009

Decision Editor: Huber R. Warner, PhD


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