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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Advance Access published online on May 12, 2009
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, doi:10.1093/gerona/glp025
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© The Author 2009. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Biologic Score and Mortality Based on a 30-Year Mortality Follow-Up: Radiation Effects Research Foundation Adult Health Study

Fumiyoshi Kasagi1, Michiko Yamada2, Hideo Sasaki2,3 and Shoichiro Fujita4

1 Department of Epidemiology
2 Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan
3 The Health Management and Promotion Center, Hiroshima Atomic Bomb Casualty Council, Japan
4 Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan

Address correspondence to Michiko Yamada, MD, Department of Clinical Studies, Radiation Effects Research Foundation, 5-2 Hijiyama Park, Minami-ku, Hiroshima 732–0815, Japan. Email: yamada{at}rerf.or.jp


  Abstract

This study aimed to test whether scored biologic functions can predict individual life expectancies and to investigate the disease-related and time-related differences in evaluated associations. A biologic score was defined as the first principal component score of the five physiological tests. Study participants were 4,871 people aged 35–74 years at baseline examination in 1970–1972 and followed until the end of 1999. We evaluated the prognostic value of the biologic score by Cox proportional hazard analysis. In all age and sex groups, increasing trends of mortality for all diseases by increment of biologic score were observed after adjustment for potential risk factors. The validity of the biologic score was significant throughout the entire study period. Each disease except cancer showed a significant association with biologic score at baseline examination. In conclusion, the biologic score is a valid predictor of life span in this large-scale prospective study of middle-aged and elderly Japanese.

Keywords Biologic score; Cohort study; Mortality; Longitudinal study

Received: September 15, 2008; Accepted: February 11, 2009

Decision Editor: Huber R. Warner, PhD


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