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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Advance Access originally published online on May 4, 2009
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2009 64A(7):752-760; doi:10.1093/gerona/glp049
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© The Author 2009. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Aging-Related Alterations of Subtelomeric Methylation in Sarcoidosis Patients

Toyoki Maeda, Jing Zhi Guan, Yoshihiro Higuchi, Jun-ichi Oyama and Naoki Makino

Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Tsurumihara, Beppu, Oita, Japan

Address correspondence to Toyoki Maeda, MD, PhD, Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Beppu, Oita 874-0838, Japan. Email:maedat{at}beppu.kyushu-u.ac.jp


  Abstract

Telomeres in somatic cells become shorter with aging, and the shortening is accelerated by pathophysiological conditions. Telomere shortening can be influenced by subtelomeric DNA methylation. The telomere length and subtelomeric methylation status in peripheral leukocytes were compared in healthy controls and sarcoidosis patients. The sarcoidosis patients revealed shorter telomeres and a faster attrition of telomere shortening in comparison with healthy controls. Both healthy controls and sarcoidosis patients showed that long telomeres (>9.4 kb) decrease and short telomeres (<4.4 kb) increase with aging, accompanying relative increases of long telomeres with subtelomeric hypermethylation and short telomeres with subtelomeric hypomethylation. This suggested that the aging-related telomere shortening is associated with the surrounding subtelomeric hypomethylation. Furthermore, sarcoidosis patients showed this alteration of the subtelomeric methylation earlier than controls (in their 60s or later). This altered subtelomeric hypomethylation may correspond to the accelerated telomere shortening in sarcoidosis. This also means that the subtelomeric hypomethylation can be also influenced by certain disease conditions.

Keywords Sarcoidosis; DNA methylation; Subtelomere; Telomere; Aging

Received: December 15, 2008; Accepted: March 7, 2009

Decision Editor: Huber R. Warner, PhD


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