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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Advance Access originally published online on March 20, 2009
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2009 64A(5):540-549; doi:10.1093/gerona/glp021
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© The Author 2009. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Exercise Training Modulates the Nitric Oxide Synthase Profile in Skeletal Muscle From Old Rats

Wook Song1,2, Hyo-Bum Kwak1, Jong-Hee Kim1 and John M. Lawler1

1 Department of Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, and the Intercollegiate Faculty of Nutrition, Texas A&M University, College Station
2 Health and Exercise Science Laboratory, Institute of Sports Science, Seoul National University, Korea

Address correspondence to John M. Lawler, PhD, Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Intercollegiate Faculty of Nutrition, Texas A&M University, College Station, TX 77843-4243. Email: jml2621{at}neo.tamu.edu


  Abstract

The effects of exercise training on the nitric oxide synthase (NOS) isoform profile in aging fast-twitch (white gastrocnemius [WG]) and slow-twitch (soleus [SOL]) muscle have not been investigated. Six-month and 27-month male Fischer-344 rats were divided into the following groups: young sedentary (YS), young treadmill exercise trained for 12 weeks, old sedentary (OS), and old exercise trained (OE). Inducible NOS (iNOS) protein expression and activity were significantly higher in OS compared with YS, whereas exercise training significantly reduced iNOS protein and activity levels in the WG. Neuronal NOS protein expression decreased with aging in WG but was upregulated significantly with exercise training in OE for both WG and SOL. Endothelial NOS (eNOS) protein levels were depressed in WG of old rats but were higher in OE than in OS. eNOS was unaffected by aging or exercise in the SOL. Our results indicate that endurance exercise training attenuates age-induced alterations of NOS isoforms with a greater response in fast-twitch compared with slow-twitch muscle.

Keywords Aging; Skeletal muscle; Exercise; Nitric oxide synthase; nNOS; eNOS; iNOS

Received: December 7, 2008; Accepted: January 27, 2009

Decision Editor: Huber R. Warner, PhD


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