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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Advance Access originally published online on February 19, 2009
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2009 64A(2):175-178; doi:10.1093/gerona/gln065
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© The Author 2009. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

This article appears in the following The Journals of Gerontology Series A: Biological Sciences and Medical Sciences issue: Special Issue: Biology of Aging Summit [View the issue table of contents]

Does Damage to DNA and Other Macromolecules Play a Role in Aging? If So, How?

Judith Campisi1,2 and Jan Vijg3

1 Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California
2 Buck Institute for Age Research, Novato, California
3 Department of Genetics, Albert Einstein College of Medicine, Bronx, New York

Address correspondence to Judith Campisi, PhD, Lawrence Berkeley National Laboratory, Life Sciences Division, 1 Cyclotron Road, Berkeley, CA 94720. Email: jcampisi{at}buckinstitute.org


  Abstract

One of the most pervasive ideas regarding the causes of aging is that longevity is constrained in large measure by damage to macromolecules. An increasing body of cellular and molecular data, generated over the past decade or so, has generally supported this "damage accumulation" hypothesis of aging. There remain unanswered questions regarding which types of damage are most important for driving aging. In addition, there have been recent challenges to the damage accumulation hypothesis and a new emphasis on the importance of cellular responses and the sequelae to damage, rather damage per se. New tools and approaches are on the horizon and will need to be developed and implemented before we can fully understand whether and to what extent macromolecular damage drives aging phenotypes.

Keywords Apoptosis; Cellular senescence; Reactive oxygen species

Received: December 9, 2008; Accepted: December 10, 2008

Decision Editor: Huber R. Warner, PhD


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