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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Advance Access published online on November 11, 2009
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, doi:10.1093/gerona/glp176
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Published by Oxford University Press on behalf of The Gerontological Society of America 2009.

Prolongevity Effects of an Oregano and Cranberry Extract are Diet Dependent in the Mexican Fruit Fly (Anastrepha ludens)

Sige Zou1, James R. Carey2, Pablo Liedo3, Donald K. Ingram4, Binbing Yu5 and Reza Ghaedian6

1 Functional Genomics Unit, Laboratory of Experimental Gerontology, National Institute on Aging, Baltimore, Maryland
2 Department of Entomology, University of California, Davis
3 El Colegio de la Frontera Sur, Tapachula, Chiapas, Mexico
4 Nutritional Neuroscience and Aging Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana
5 Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Baltimore, Maryland
6 Decas Cranberry Products, Inc, Carver, Massachusetts

Address correspondence to Sige Zou, PhD, Functional Genomics Unit, Laboratory of Experimental Gerontology, National Institute on Aging, 251 Bayview Boulevard, Baltimore, MD 21224. Email: zous{at}grc.nia.nih.gov


  Abstract

Botanicals have numerous health benefits. Here, we used the Mexican fruit fly to screen 14 compounds and botanicals for their prolongevity effects and found an oregano and cranberry mixture (OC) improved survival. We then evaluated prolongevity effects of OC within the context of diet composition. Individual flies were fed 0%, 1%, or 2% OC in one of the three diets containing sugar and yeast extract (SY) at a ratio of 3:1, 9:1, or 24:1. We found that prolongevity effects of OC depended upon dose, gender, and diet composition. The greatest increase in longevity was observed in females fed the SY24:1 diet with 2% OC compared to the non-supplemented diet. OC did not reduce egg laying and, hence, did not compromise fecundity under any dietary condition tested here. This study reveals the prolongevity effects of OC and supports the emerging view that benefits of botanicals on aging depend on diet composition and gender.

Keywords Life span; Botanical extract; Aging intervention; Reproduction; Egg laying

Received: August 26, 2009; Accepted: October 13, 2009

Decision Editor: Huber R. Warner, PhD


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