Skip Navigation



The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Advance Access published online on November 9, 2009
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, doi:10.1093/gerona/glp175
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
65A/1/31    most recent
glp175v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Berryman, D. E.
Right arrow Articles by Kopchick, J. J.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Berryman, D. E.
Right arrow Articles by Kopchick, J. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Two-Year Body Composition Analyses of Long-Lived GHR Null Mice

Darlene E. Berryman1,2, Edward O. List2, Amanda J. Palmer1, Min-Yu Chung1,3, Jacob Wright-Piekarski2, Ellen Lubbers2, Patrick O'Connor4, Shigeru Okada2,5 and John J. Kopchick2,4

1 School of Human and Consumer Sciences, College of Health and Human Services
2 Edison Biotechnology Institute, Ohio University, Athens
3 Department of Nutritional Science, University of Connecticut, Storrs
4 Department of Biomedical Sciences
5 Department of Pediatrics, College of Osteopathic Medicine, Ohio University, Athens

Address correspondence to Darlene E. Berryman, PhD, RD, LD, W324 Grover Center, School of Human and Consumer Sciences, Ohio University, Athens, OH 45701. Email: berrymad{at}ohio.edu.


  Abstract

Growth hormone receptor gene–disrupted (GHR–/–) mice exhibit increased life span and adipose tissue mass. Although this obese phenotype has been reported extensively for young adult male GHR–/– mice, data for females and for other ages in either gender are lacking. Thus, the purpose of this study was to evaluate body composition longitudinally in both male and female GHR–/– mice. Results show that GHR–/– mice have a greater percent fat mass with no significant difference in absolute fat mass throughout life. Lean mass shows an opposite trend with percent lean mass not significantly different between genotypes but absolute mass reduced in GHR–/– mice. Differences in body composition are more pronounced in male than in female mice, and both genders of GHR–/– mice show specific enlargement of the subcutaneous adipose depot. Along with previously published data, these results suggest a consistent and intriguing protective effect of excess fat mass in the subcutaneous region.

Keywords Body composition; Growth hormone; Obesity; Adipose depots; Gender differences

Received: August 24, 2009; Accepted: October 14, 2009

Decision Editor: Huber R. Warner, PhD


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.