The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Advance Access published online on July 23, 2009
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, doi:10.1093/gerona/glp099
Survival in Older Men May Benefit From Being Slightly Overweight and Centrally Obese—A 5-Year Follow-up Study in 4,000 Older Adults Using DXA
1 Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong, China
2 School of Public Health
3 Division of Geriatrics, Department of Medicine & Therapeutics
4 Jockey Club Centre for Osteoporosis Care and Control, The Chinese University of Hong Kong, China
Address correspondence to Tung Wai Auyeung, MB ChB, Department of Medicine and Geriatrics, Tuen Mun Hospital, Tuen Mun, Hong Kong, China. Email: auyeungtw{at}cuhk.edu.hk
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Abstract |
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Background: Whether overweight in old age is hazardous remains controversial. Body mass index (BMI) overestimates adiposity and fails to measure central adiposity. We used dual-energy x-ray absorptiometry (DXA) to measure adiposity and hypothesized that overall adiposity, distribution of adiposity, and muscle mass might individually affect survival.
Methods: We recruited 2000 men and 2000 women aged 65 years or older. Baseline BMI, waist–hip ratio (WHR), body fat index (BFI = total body fat/height square), relative truncal fat (RTF = trunk fat/total body fat), and body muscle mass index (BMMI = total body muscle mass/height square) were measured. Mortality was ascertained by death registry after 63.3 (median) months.
Results: Two hundred and forty-two men and 78 women died. In men, mortality hazard ratio (HR) decreased consistently by 0.85 (p < .005), 0.86 (p < .005), and 0.86 (p < .005) per every quintile increase in BMI, BFI, and BMMI, respectively. A J-shaped relationship was observed in central adiposity (RTF and WHR) quintiles; the minimum values were at the 3rd WHR quintile (0.92–0.94) and 4th RTF quintile (mean WHR, 0.94). When RTF was tested with BFI, both high and low central adiposity were unfavorable while general adiposity became marginally insignificant (p = 0.062). When BFI and BMMI were tested together, increasing adiposity rather than muscle mass favored survival (BFI quintile, HR 0.97, p .015; BMMI quintile, HR 1.00, p .997).
Conclusions: Older men were resistive to hazards of overweight and adiposity; and mild-grade overweight, obesity, and even central obesity might be protective. This may bear significant implication on the recommended cutoff values for BMI and WHR in the older population.
Keywords mortality; adiposity; BMI; muscles
Received: March 1, 2009; Accepted: June 11, 2009