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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Advance Access published online on April 6, 2009
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, doi:10.1093/gerona/glp036
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© The Author 2009. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Insulin-Like Growth Factors and Leukocyte Telomere Length: The Cardiovascular Health Study

Robert C. Kaplan1, Annette L. Fitzpatrick2, Michael N. Pollak3, Jeffrey P. Gardner4, Nancy S. Jenny5, Aileen P. McGinn1, Lewis H. Kuller6, Howard D. Strickler1, Masayuki Kimura4, Bruce M. Psaty2,7,8 and Abraham Aviv4

1 Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York
2 Department of Epidemiology, University of Washington, Seattle
3 Cancer Prevention Research Unit, Departments of Medicine and Oncology, Lady Davis Research Institute of Jewish General Hospital and McGill University, Montreal, Quebec, Canada
4 The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark
5 Department of Pathology, University of Vermont College of Medicine, Burlington
6 Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania
7 Department of Health Services
8 Department of Medicine, University of Washington, Seattle

Address correspondence to Robert C. Kaplan, PhD, Albert Einstein College of Medicine, Belfer 1306C, 1300 Morris Park Avenue, Bronx, NY 10461. Email: rkaplan{at}aecom.yu.edu


  Abstract

The insulin-like growth factor (IGF) axis may affect immune cell replicative potential and telomere dynamics. Among 551 adults 65 years and older, leukocyte telomere length (LTL), insulin-like growth factor-1 (IGF-1), and insulin-like growth factor–binding proteins 1 and 3 (IGFBP-1, IGFBP-3) were measured. Multivariate linear regression was used to model the association of LTL with IGF-1 and IGFBPs, while controlling for confounding and increasing precision by adjusting for covariates. We observed a significant association between higher IGF-1 and longer LTL after adjustment for age, sex, race, smoking status, body mass index, hypertension, diabetes, and serum lipids. The results suggested an increase of .08 kb in LTL for each standard deviation increase of IGF-1 (p = .04). IGFBP-1 and IGFBP-3 were not significantly associated with LTL. High IGF-1 may be an independent predictor of longer LTL, consistent with prior evidence suggesting a role for IGF-1 in mechanisms relating to telomere maintenance.

Keywords Insulin-like growth factor; Telomere length; Epidemiology

Received: December 18, 2008; Accepted: February 24, 2009

Decision Editor: Huber R. Warner, PhD


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