Skip Navigation



The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Advance Access published online on February 18, 2009
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, doi:10.1093/gerona/gln072
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
64A/2/179    most recent
gln072v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Miller, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miller, R. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

This article appears in the following The Journals of Gerontology Series A: Biological Sciences and Medical Sciences issue: Special Issue: Biology of Aging Summit Perspective [View the issue table of contents]

Cell Stress and Aging: New Emphasis on Multiplex Resistance Mechanisms

Richard A. Miller1,2

1 Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor
2 Ann Arbor VA Medical Center, Michigan

Address correspondence to Richard A. Miller, MD, PhD, Department of Pathology and Geriatrics Center, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200. Email: millerr{at}umich.edu


  Abstract

Work, initially in Caenorhabditis elegans and then more recently in fruit flies and mice, has suggested that anti-aging mutations extend life span by simultaneous activation of pathways that protect cells from multiple forms of injury. This "multiplex stress resistance" theory suggests a number of new avenues for investigation of the genetic and cellular controls that influence organismic longevity within and among species, and that might lead to the development of pharmaceuticals that retard the aging process and, therefore, the entire panoply of age-dependent diseases and disabilities.

Keywords Longevity; Cell injury; Overview; Comparative biology

Received: December 9, 2008; Accepted: December 10, 2008

Decision Editor: Huber R. Warner, PhD


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.