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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Advance Access originally published online on April 17, 2009
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2009 64A(9):968-974; doi:10.1093/gerona/glp044
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© The Author 2009. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Multiparametric NMR-Based Assessment of Skeletal Muscle Perfusion and Metabolism During Exercise in Elderly Persons: Preliminary Findings

D. Walter Wray1,2,3, Steven K. Nishiyama1, Aurélien Monnet4, Claire Wary4, Sandrine Duteil4, Pierre G. Carlier4 and Russell S. Richardson1,2,3,5

1 Department of Internal Medicine, University of California San Diego, La Jolla
2 Department of Medicine, Division of Geriatrics, University of Utah, VAMC Salt Lake City, Salt Lake City
3 Geriatric Research, Education, and Clinical Center, Salt Lake City VAMC, Utah
4 NMR Laboratory, Association Institut de Myologie–Commissariat à l'Energie Atomique, Institute de Myologie, Pitié Salpêtrière University Hospital, Paris, France
5 Department of Exercise and Sport Science, University of Utah, Salt Lake City

Address correspondence to D. Walter Wray, PhD, Department of Internal Medicine, Division of Geriatrics, University of Utah, VAMC Salt Lake City, Building 2, 1C03, 500 Foothill Drive, Salt Lake City, UT 84132. Email: walter.wray{at}hsc.utah.edu


  Abstract

Background: Aging is associated with a decline in exercise capacity that may be attributable to maladaptations in both skeletal muscle perfusion and metabolism; yet very little is known regarding the real-time, within-muscle interplay between these parameters during physical activity. Therefore, we utilized an unique nuclear magnetic resonance sequence to concomitantly examine changes in lower leg skeletal muscle perfusion and metabolism.

Methods: In young (26 ± 5 years, n = 6) and older (70 ± 5 years, n = 6) healthy volunteers, arterial spin labeling measurements of muscle perfusion were combined with 31 Phosphorous (31P) nuclear magnetic resonance spectroscopy to monitor high-energy phosphate metabolites during and after 5 minutes of moderate-intensity ({approx}5W) plantar flexion exercise.

Results: Compared with young, end-exercise perfusion was diminished in older participants (43 ± 10 mL/100 g/minute, old; 60 ± 7 mL/100 g·minute, young), accompanied by greater phosphocreatine (PCr) depletion (–28% ± 12%, old; –19% ± 7%, young) and elevated inorganic phosphate/PCr (0.41 ± 0.2, old; 0.24 ± 0.09, young); yet the time constant for PCr recovery ({tau}, an index of muscle oxidative capacity) was similar between groups (51 ± 17 seconds, old; 48 ± 7 seconds, young).

Conclusions: Together, these preliminary data provide evidence of an age-related decline in tissue perfusion and increased "metabolic stress" during exercise but demonstrate that overall oxidative capacity in the elderly does not appear negatively affected by this relatively hypoperfused state.

Keywords 31P spectroscopy; Oxidative capacity; Exercise; Aging

Received: February 10, 2009; Accepted: February 22, 2009

Decision Editor: Luigi Ferrucci, MD, PhD


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