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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Advance Access originally published online on October 6, 2009
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2009 64A(12):1232-1239; doi:10.1093/gerona/glp146
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© The Author 2009. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Effects of Chronic Overload on Muscle Hypertrophy and mTOR Signaling in Young Adult and Aged Rats

Angela Chalé-Rush, Evan P. Morris, Tracee L. Kendall, Naomi E. Brooks and Roger A. Fielding

Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts

Address correspondence to Roger A. Fielding, PhD, Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111. Email: roger.fielding{at}tufts.edu


  Abstract

We examined the effect of 28 days of overload on mammalian target of rapamycin (mTOR) and extracellular signal–regulated kinase (ERK) signaling in young adult (Y; 6-month old) and aged (O; 30-month old) Fischer 344 x Brown Norway rats subjected to bilateral synergist ablation (SA) of two thirds of the gastrocnemius muscle or sham surgery (CON). Although plantaris (PLA) muscle hypertrophy was attenuated by aging, mTOR phosphorylation was 44% and 35% greater in Y SA and O SA compared with CON (p = .038). Ribosomal protein S6 phosphorylation was 114% and 24% higher in Y SA and O SA compared with CON (p = .009). Eukaryotic initiation factor 2B{epsilon} phosphorylation was 33% and 9% higher in Y SA and O SA compared with CON (p = .04). Translational signaling in young adult and aged plantaris muscle is equally responsive to chronic overload.

Keywords mTOR; Muscle hypertrophy; Muscle overload; Aging

Received: May 28, 2009; Accepted: September 4, 2009

Decision Editor: Huber R. Warner, PhD


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