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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Advance Access originally published online on September 23, 2009
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2009 64A(12):1207-1211; doi:10.1093/gerona/glp134
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© The Author 2009. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Transplantation of Young Ovaries to Old Mice Increased Life Span in Transplant Recipients

Jeffrey B. Mason1,2, Shelley L. Cargill1,3, Gary B. Anderson1 and James R. Carey4

1 Department of Animal Science, University of California, Davis
2 Present address: Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square
3 Present address: Department of Biological Sciences, San Jose State University, California
4 Department of Entomology, University of California, Davis

Address correspondence to Jeffrey B. Mason, PhD, Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, 382 West Street Road, Kennett Square, PA 19348. Email: masonjef{at}vet.upenn.edu


  Abstract

Previously we reported that prepubertally ovariectomized mice that received young transplanted ovaries at a postreproductive age showed a 40% increase in life expectancy. To study this phenomenon in greater detail, 11-month-old ovariectomized and ovary-intact CBA/J mice underwent ovarian transplantation with 60-day-old ovaries or a sham surgery. Results from observations on transplant recipients in the current study extended our previous results. Whereas intact control mice lived an average of 726 days, transplant recipients lived an average of 770 days (i.e., 780 days for intact recipients and 757 days for ovariectomized recipients). If intact recipients had ceased reproductive cycling by the time of transplant, we observed a further increase in mean life span to 811 days. These results demonstrate that young ovaries enhanced longevity when transplanted to old mice and that ovarian status, examined by means of ovariectomy and ovarian transplantation, clearly influenced the potential of young transplanted ovaries to positively impact longevity.

Keywords Life-span extension; Ovariectomy; Ovary transplant; Gonadal manipulation; CBA/J

Received: November 19, 2008; Accepted: August 27, 2009

Decision Editor Huber R. Warner, PhD


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