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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Advance Access originally published online on August 19, 2009
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2009 64A(11):1146-1153; doi:10.1093/gerona/glp118
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Published by Oxford University Press on behalf of The Gerontological Society of America 2009.

Age-Related Changes of Claudin Expression in Mouse Liver, Kidney, and Pancreas

Theresa D’Souza1, Cheryl A. Sherman-Baust1, Suresh Poosala2, James M. Mullin3 and Patrice J. Morin1,4

1 Laboratory of Cellular and Molecular Biology
2 Research Resource Branch, National Institute on Aging, Baltimore, Maryland
3 Lankenau Institute for Medical Research, Wynnewood, Pennsylvania
4 Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland

Address correspondence to Patrice J. Morin, Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Room 6C228, Baltimore, MD 21224. Email: morinp{at}mail.nih.gov.


  Abstract

Tight junctions (TJs) play crucial roles in tissue homeostasis and inflammation through their roles in the control of paracellular transport and barrier function. There is evidence that these functions are compromised in older organisms, but the exact mechanisms leading to TJ deterioration are not well understood. Claudin proteins are a family of membrane proteins that constitute the structural barrier elements of TJs and therefore play a major role in their formation and function. Using immunohistochemistry and immunoblotting, we have studied the expression of six different claudin proteins (claudin-1, -2, -3, -4, -5, and -7) in three tissues (liver, kidney, and pancreas) of aging male and female mice. In general, we find an age-dependent decrease in the expression of several claudin proteins in all three tissues observed, although the exact changes are tissue specific. Our findings provide a possible basis for the decrease in tissue barrier function in older organisms.

Keywords Claudin; Aging; Tight junction; Immunohistochemistry

Received: December 29, 2008; Accepted: July 22, 2009

Decision Editor: Huber R. Warner, PhD


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