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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Advance Access originally published online on July 28, 2009
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2009 64A(11):1107-1113; doi:10.1093/gerona/glp101
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© The Author 2009. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Calorie Restriction Enhances T-Cell–Mediated Immune Response in Adult Overweight Men and Women

Tanvir Ahmed1,2, Sai Krupa Das3,4, Julie K. Golden3, Edward Saltzman3,4, Susan B. Roberts3,4 and Simin Nikbin Meydani1,4,5

1 Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts
2 Present address: International Centre for Diarrhoeal Disease Research, GPO Box 128, Dhaka 1000, Bangladesh
3 Energy Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts
4 Friedman School of Nutrition Science and Policy
5 Department of Pathology, Sackler Graduate School of Biochemical Sciences, Tufts University, Boston, Massachusetts

Address correspondence to Simin N. Meydani, DVM, PhD, Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111. E-mail: simin.meydani{at}tufts.edu


  Abstract

Calorie restriction (CR) enhances immune response and prolongs life span in animals. However, information on the applicability of these results to humans is limited. T-cell function declines with age. We examined effects of CR on T-cell function in humans. Forty-six overweight, nonobese participants aged 20–42 years were randomly assigned to 30% or 10% CR group for 6 months. Delayed-type hypersensitivity (DTH), T-cell proliferation (TP), and prostaglandin E2 (PGE2) productions were determined before and after CR. DTH and TP to T-cell mitogens were increased in both groups over baseline (p ≤ .019). However, number of positive responses to DTH antigens (p = .016) and TP to anti-CD3 reached statistical significance only after 30% CR (p = .001). Lipopolysaccharide-stimulated PGE2 was reduced in both groups but reached statistical significance after 30% CR (p ≤ .029). These results, for the first time, show that 6-month CR in humans improves T-cell function.

Keywords Calorie restriction; T cell; Immune response; Aging; Obesity

Received: March 4, 2009; Accepted: July 2, 2009

Decision Editor: Huber R. Warner, PhD


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